I just found a way to run GTA: San Andreas simply by a DVD while it is not installed on your system.
That means that you won’t need to have that 5GB space always reserved on your harddisk for the game.
And you can simply insert the DVD and play whenever and wherever you want!
To make your DVD, you will first need to install the game.
Then you will need a NO-CD or NO-DVD crack so that the game runs without the need of detecting any external CD/DVD.
Next, Using a DVD Burner, you have to burn all the game installed files to a DVD. But if you use a DVD+R/-R then you will be gettin only 4.37 GB space whereas a full install of the game occupies 5+ GB. So you won’t be able to fit it directly on the DVD..
You can remove the GTASA radio files from your installed directory to free some space (around 1GB). if you need help removing Radio files click here.
Now you have got the installed files which occupy around 4 GB space.
So just burn the installed files onto a DVD.
Now you can merely uninstall the game from your hard disk using the original game disc.
Now whenver you need to run the game, just insert you created DVD and play the Game!!